Bhalla's "Mechanisms of ENaC Regulation and Clinical Implications" 2008
From Biol557
- ENaC is likely a trimeric protein with alpha, beta, and gamma subunits.
- There are many ways that ENaC can be inhibited from bringing Na into the cell:
- Ubiquitination
- Inhibition by sodium concentration inside the cell
- Lack of AMP
- Phosphorylation (we know it gets phosphorylated but we don't know what this achieves)
- Trafficking regulation,
- Hormonal
- Extrinsic factors (proteolytic cleavage, mechanosensation)