Bhalla's "Mechanisms of ENaC Regulation and Clinical Implications" 2008

From Biol557

  • ENaC is likely a trimeric protein with alpha, beta, and gamma subunits.
  • There are many ways that ENaC can be inhibited from bringing Na into the cell:
    • Ubiquitination
    • Inhibition by sodium concentration inside the cell
    • Lack of AMP
    • Phosphorylation (we know it gets phosphorylated but we don't know what this achieves)
    • Trafficking regulation,
    • Hormonal
    • Extrinsic factors (proteolytic cleavage, mechanosensation)
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