Are you going to follow my orders?
From Create Your Own Story
YOU: I need to know that you're going to follow my orders. I can't have you running off to lick the Illusive Man's boots while we're on a mission.
MIRANDA: Look, Commander, I don't think you understand our relationship here. I'm working for you because you're working for Cerberus. That's it. You cross the line, and I'm out. I'll follow your command, Shepard- I didn't bring you back just to second-guess your orders - but we both know who my real boss is.
You realize that there really isn't any option that will make MIRANDA less BITCHY.