Muchatuta's "Structural and Functional Analysis of Liver Cysts from the BALB/c-cpk Mouse Model of PKD" 2009
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(Created page with '===Abstract=== *Liver bile duct cysts occur in ADPKD and ARPKD. *They used light and electron microscopy to examine the ductal epithelial cells in wildtype, diseased-pre-cyst, an…')
(Created page with '===Abstract=== *Liver bile duct cysts occur in ADPKD and ARPKD. *They used light and electron microscopy to examine the ductal epithelial cells in wildtype, diseased-pre-cyst, an…')
Current revision as of 13:45, 27 April 2010
[edit] Abstract
- Liver bile duct cysts occur in ADPKD and ARPKD.
- They used light and electron microscopy to examine the ductal epithelial cells in wildtype, diseased-pre-cyst, and disease-cyst mouse models.
- They found fibrosis and shortened primary cilia in the diseased states (expression of the mutated cpk gene).
- They showed that ENaC was either absent or inactive in the diseased cells.
- See lecture notes for the rest as the paper is long.
